{"id":7097,"date":"2022-08-10T19:04:47","date_gmt":"2022-08-10T19:04:47","guid":{"rendered":"https:\/\/thcinct.com\/karxt-schizophrenia-win-cbd-for-anxiety-no-nuplazid-for-alzheimers-psychosis\/"},"modified":"2022-08-10T19:04:47","modified_gmt":"2022-08-10T19:04:47","slug":"karxt-schizophrenia-win-cbd-for-anxiety-no-nuplazid-for-alzheimers-psychosis","status":"publish","type":"post","link":"https:\/\/thcinct.com\/?p=7097","title":{"rendered":"KarXT Schizophrenia Win; CBD for Anxiety; No Nuplazid for Alzheimer&#8217;s Psychosis"},"content":{"rendered":"<p><\/p>\n<p>The <a href=\"https:\/\/investors.karunatx.com\/news-releases\/news-release-details\/karuna-therapeutics-announces-positive-results-phase-3-emergent\" target=\"_blank\" rel=\"noopener\">EMERGENT-2 phase III trial<\/a> met its primary objective by achieving a significant reduction in PANSS total score with oral KarXT (xanomeline-trospi) versus placebo in people with schizophrenia, Karuna Therapeutics announced.<\/p>\n<p>Up to 87% of <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0955395922002031\" target=\"_blank\" rel=\"noopener\">people with opioid use disorder<\/a> may not be receiving life-saving medications such as methadone, buprenorphine, and naltrexone.  (International Journal of Drug Policy)<\/p>\n<p>After 12 weeks, young people with <a href=\"https:\/\/www.psychiatrist.com\/jcp\/anxiety\/cannabidiol-treatment-resistant-anxiety-disorders-young-people-open-label-trial\/\" target=\"_blank\" rel=\"noopener\">anxiety resistant to cannabidiol treatment<\/a> had an average decrease of 42.6% in symptom severity.  &#8220;Young people had fewer panic attacks and were able to do things they couldn&#8217;t do before,&#8221; said Paul Amminger, MD, PhD, of Orygen in Australia.  (Journal of Clinical Psychiatry)<\/p>\n<p>Often children of people with Alzheimer&#8217;s <a href=\"https:\/\/www.nytimes.com\/2022\/08\/02\/well\/mind\/alzheimers-caregivers.html\" target=\"_blank\" rel=\"noopener\">feel fear and anxiety<\/a> of his own diagnosis one day.  (New York News)<\/p>\n<p>After a negative review by an advisory committee earlier this year, the <a href=\"https:\/\/acadia.com\/media\/news-releases\/acadia-pharmaceuticals-receives-complete-response-letter-from-u-s-fda-for-supplemental-new-drug-application-for-pimavanserin-for-the-treatment-of-hallucinations-and-delusions-associated-with-alzheime\" target=\"_blank\" rel=\"noopener\">FDA rejected pimavanserin (Nuplazid)<\/a> for an additional indication for the treatment of hallucinations and delusions associated with the psychosis of Alzheimer&#8217;s disease, Acadia Pharmaceuticals said.<\/p>\n<p>Children with <a href=\"https:\/\/www.thelancet.com\/journals\/lanpsy\/article\/PIIS2215-0366(22)00207-3\/fulltext\" target=\"_blank\" rel=\"noopener\">genetic intellectual disability<\/a> had a much higher risk of developing neuropsychiatric conditions, according to the UK-based IMAGINE study.  (The Lancet Psychiatry)<\/p>\n<p>Older Americans still feel the mental burden of the <a href=\"https:\/\/thehill.com\/opinion\/healthcare\/3588849-older-americans-need-action-on-mental-health-and-behavioral-health-crises\/\" target=\"_blank\" rel=\"noopener\">covid-19 pandemic<\/a>.  (the hill)<\/p>\n<p>A Mendelian randomization study found that global cortical thickness could be used <a href=\"https:\/\/jamanetwork.com\/journals\/jamapsychiatry\/fullarticle\/2795312\" target=\"_blank\" rel=\"noopener\">predict alcohol consumption<\/a> and excessive alcohol consumption behaviors.  (JAMA Psychiatry)<\/p>\n<p>                                <\/p>\n<p>Kristen Monaco is a staff writer, focusing on endocrinology, psychiatry and nephrology news.  Based in the New York City office, he has been with the firm since 2015.  <\/p>\n<p><a href=\"https:\/\/www.medpagetoday.com\/psychiatry\/generalpsychiatry\/100157\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The EMERGENT-2 phase III trial met its primary objective by achieving a significant reduction in PANSS total score with oral KarXT (xanomeline-trospi) versus placebo in people with schizophrenia, Karuna Therapeutics announced. Up to 87% of people with opioid use disorder may not be receiving life-saving medications such as methadone, buprenorphine, and naltrexone. (International Journal of Drug Policy) After 12 weeks, young people with anxiety resistant to cannabidiol treatment had an average decrease of 42.6% in symptom severity. &#8220;Young people had fewer panic attacks and were able to do things they couldn&#8217;t do before,&#8221; said Paul Amminger, MD, PhD, of Orygen&#8230; <\/p>\n","protected":false},"author":1,"featured_media":7098,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/clf1.medpagetoday.com\/media\/images\/author\/kristenMonaco_188.jpg","fifu_image_alt":"","footnotes":""},"categories":[2],"tags":[],"class_list":["post-7097","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-featured"],"jetpack_featured_media_url":"https:\/\/clf1.medpagetoday.com\/media\/images\/author\/kristenMonaco_188.jpg","_links":{"self":[{"href":"https:\/\/thcinct.com\/index.php?rest_route=\/wp\/v2\/posts\/7097","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/thcinct.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/thcinct.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/thcinct.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/thcinct.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=7097"}],"version-history":[{"count":0,"href":"https:\/\/thcinct.com\/index.php?rest_route=\/wp\/v2\/posts\/7097\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/thcinct.com\/index.php?rest_route=\/wp\/v2\/media\/7098"}],"wp:attachment":[{"href":"https:\/\/thcinct.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=7097"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/thcinct.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=7097"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/thcinct.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=7097"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}